What the FDA labels say about taking them together
Mycophenolate mofetil and sirolimus
Sirolimus's FDA label of January 28, 2026 names mycophenolate mofetil in its warnings and precautions section; the mycophenolate mofetil labels PlainMeds reads (2) do not name sirolimus.
Check it at the source: the mycophenolate mofetil FDA label on DailyMed (effective August 5, 2026, Genentech, Inc.); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the mycophenolate mofetil label say about sirolimus?
Mycophenolate mofetil's label (effective August 5, 2026) and its 1 other brand-application label do not name sirolimus in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CellCept), NDA050722 (Roche Palo), as published by Genentech, Inc., effective August 5, 2026 (SPL set 37241e87-4af4-4dc3-a1aa-ea6f20d8dc40), via openFDA; the full label on DailyMed
What does the sirolimus label say about mycophenolate mofetil?
Sirolimus label, warnings and precautionsIn a multicenter clinical study, de novo renal transplant patients treated with sirolimus, mycophenolate mofetil (MMF), steroids, and an IL-2 receptor antagonist had significantly higher acute rejection rates and numerically higher death rates compared to patients treated with cyclosporine, MMF, steroids, and IL-2 receptor antagonist.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mycophenolate mofetil | Sirolimus | |
|---|---|---|
| Labeled for | Organ transplant rejection | Organ transplant rejection |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.138 per capsule 250 mg capsule | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once