What the FDA labels say about taking them together
Moxifloxacin and paliperidone
Paliperidone's FDA label of January 31, 2025 names moxifloxacin in its warnings and precautions section; moxifloxacin's label does not name paliperidone itself but warns about its class (Atypical antipsychotics).
Check it at the source: the moxifloxacin FDA label on DailyMed (effective March 17, 2026, Macleods Pharmaceuticals Limited); the paliperidone FDA label on DailyMed (effective January 31, 2025, Janssen Pharmaceuticals, Inc.).
What does the moxifloxacin label say about paliperidone?
Moxifloxacin's label does not name paliperidone itself; it warns about its class (Atypical antipsychotics):
Moxifloxacin label, warnings and precautionsKnown prolongation of the QT interval Ventricular arrhythmias including torsade de pointes because QT prolongation may lead to an increased risk for these conditions Ongoing proarrhythmic conditions, such as clinically significant bradycardia and acute myocardial ischemia, Uncorrected hypokalemia or hypomagnesemia Class IA (for example, quinidine, procainamide) or Class III (for example, amiodarone, sotalol) antiarrhythmic agents Other drugs that prolong the QT interval such as cisapride, erythromycin …
Moxifloxacin label, warnings and precautionsPharmacokinetic studies between moxifloxacin and other drugs that prolong the QT interval such as cisapride, erythromycin, antipsychotics, and tricyclic antidepressants have not been performed.
Source: FDA drug label (Moxifloxacin), Macleods Pharmaceuticals Limited, effective March 17, 2026 (SPL set 182ecd0f-714f-42f0-9b16-fb604cf15786), via openFDA; the full label on DailyMed
What does the paliperidone label say about moxifloxacin?
Paliperidone label, warnings and precautionsThe use of paliperidone should be avoided in combination with other drugs that are known to prolong QTc including Class 1A (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications, antipsychotic medications (e.g., chlorpromazine, thioridazine), antibiotics (e.g., gatifloxacin, moxifloxacin), or any other class of medications known to prolong the QTc interval.
Source: FDA drug label (INVEGA), Janssen Pharmaceuticals, Inc., effective January 31, 2025 (SPL set 7b8e5b26-b9e4-4704-921b-3c3c0d159916), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Moxifloxacin | Paliperidone | |
|---|---|---|
| Labeled for | Bacterial infections | Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.60 per mL 0.5% eye drops | $0.972 per tablet 3 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once