What the FDA labels say about taking them together
Morphine and tranylcypromine
Morphine's FDA label of July 13, 2026 names tranylcypromine in its drug interactions section; tranylcypromine's label does not name morphine itself but warns about its class (Opioids (opioid agonists)). The morphine label: “MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity.”
Check it at the source: the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack); the tranylcypromine FDA label on DailyMed (effective July 2, 2025, Advanz Pharma (US) Corp.).
What does the morphine label say about tranylcypromine?
Morphine label, drug interactionsMonoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (…). Intervention: Do not use morphine sulfate in patients taking MAOIs or within 14 days of stopping such treatment. Examples: phenelzine, tranylcypromine, linezolid
Morphine Sulfate label (Fresenius Kabi, USA LLC, August 31, 2026), drug interactionsMonoamine Oxidase Inhibitors (MAOIs) Clinical Impact: MAOI interactions with opioids may manifest as serotonin syndrome or opioid toxicity (…). … monitoring blood pressure and signs and symptoms of CNS and respiratory depression. Examples: phenelzine, tranylcypromine, linezolid
Source: FDA drug label (Ms Contin, NDA019516), Rhodes Pharmaceuticals LLC, effective August 14, 2026 (SPL set c354b3bf-86c0-4bb8-8b1f-be2164942698), via openFDA
Source: FDA drug label (Morphine Sulfate, NDA204223), Fresenius Kabi, USA LLC, effective August 31, 2026 (SPL set 1f53de80-efc8-4930-b3e3-fba0d026af05), via openFDA
Source: FDA drug label (Morphine Sulfate, NDA022195), Hikma Pharmaceuticals USA Inc., effective February 3, 2026 (SPL set ca359246-4674-4b32-b8b2-673d32b7112f), via openFDA
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
What does the tranylcypromine label say about morphine?
Tranylcypromine's label does not name morphine itself; it warns about its class (Opioids (opioid agonists)):
Tranylcypromine label, drug interactionsExcessive reduction of blood glucose (additive effect) f CNS depressant agents (including opioids, alcohol, sedatives, hypnotics) Use with caution d Increased CNS depression Dietary supplements containing sympathomimetics Contraindicated a Antidepressants including but not limited to:
Source: FDA drug label (PARNATE), Advanz Pharma (US) Corp., effective July 2, 2025 (SPL set b72d8187-dfcc-4ea0-b5e9-c0be95b69a27), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Morphine | Tranylcypromine | |
|---|---|---|
| Labeled for | Pain | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.226 per tablet 15 mg tablet | $0.591 per tablet 10 mg tablet |
| Shortage now | In shortage | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once