What the FDA labels say about taking them together
Morphine and pralidoxime
Pralidoxime's FDA label of April 1, 2026 names morphine in its drug interactions section; the morphine labels PlainMeds reads (4) do not name pralidoxime. The pralidoxime label: “… anticholinesterases, they should be used cautiously in the treatment of convulsions; morphine, theophylline, aminophylline, reserpine, and phenothiazine-type tranquilizers should be avoided in patients with …”
Check it at the source: the morphine FDA label on DailyMed (effective July 13, 2026, Bryant Ranch Prepack); the pralidoxime FDA label on DailyMed (effective April 1, 2026, Baxter Healthcare Corporation).
What does the morphine label say about pralidoxime?
Morphine's label (effective July 13, 2026) and its 3 other brand-application labels do not name pralidoxime in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Morphine sulfate), ANDA078761 (Sun Pharm Inds Ltd), as published by Bryant Ranch Prepack, effective July 13, 2026 (SPL set 595243fe-a4b1-479a-99d6-a084a4181891), via openFDA; the full label on DailyMed
What does the pralidoxime label say about morphine?
Pralidoxime label, drug interactionsThe following precautions should be kept in mind in the treatment of anticholinesterase poisoning, although they do not bear directly on the use of pralidoxime chloride: since barbiturates are potentiated by the anticholinesterases, they should be used cautiously in the treatment of convulsions; morphine, theophylline, aminophylline, reserpine, and phenothiazine-type tranquilizers should be avoided in patients with organophosphate poisoning.
Source: FDA drug label (Protopam Chloride), Baxter Healthcare Corporation, effective April 1, 2026 (SPL set 2741d8fd-51c2-46be-880b-99f2b20a6137), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Morphine | Pralidoxime | |
|---|---|---|
| Labeled for | Pain | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.226 per tablet 15 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once