What the FDA labels say about taking them together
Modafinil and triazolam
Modafinil's FDA label of October 16, 2025 names triazolam in its drug interactions section; the triazolam label PlainMeds reads does not name modafinil. The modafinil label: “DRUG INTERACTIONS Effects of PROVIGIL on CYP3A4/5 Substrates The clearance of drugs that are substrates for CYP3A4/5 may be increased by PROVIGIL via induction of metabolic enzymes, which results in lower systemic …”
Check it at the source: the modafinil FDA label on DailyMed (effective October 16, 2025, Golden State Medical Supply, Inc.); the triazolam FDA label on DailyMed (effective July 10, 2026, Mylan Pharmaceuticals Inc.).
What does the modafinil label say about triazolam?
Modafinil label, drug interactionsDRUG INTERACTIONS Effects of PROVIGIL on CYP3A4/5 Substrates The clearance of drugs that are substrates for CYP3A4/5 (e.g., steroidal contraceptives, cyclosporine, midazolam, and triazolam) may be increased by PROVIGIL via induction of metabolic enzymes, which results in lower systemic exposure.
Source: FDA drug label (Provigil), NDA020717 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective October 16, 2025 (SPL set 3b8d1c32-dac9-50e6-e063-6394a90aa5a5), via openFDA; the full label on DailyMed
What does the triazolam label say about modafinil?
Triazolam's label (effective July 10, 2026) does not name modafinil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Triazolam), NDA017892 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective July 10, 2026 (SPL set 5add318e-11b9-42f8-b052-0d8cebb32fcf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Modafinil | Triazolam | |
|---|---|---|
| Labeled for | n/a | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.344 per tablet 200 mg tablet | $0.308 per tablet 0.25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once