What the FDA labels say about taking them together
Mitotane and spironolactone
Mitotane's FDA label of March 3, 2026 names spironolactone in its drug interactions section, and spironolactone's label names mitotane too. The spironolactone label: “Avoid concomitant use of ALDACTONE and mitotane.”
Check it at the source: the mitotane FDA label on DailyMed (effective March 3, 2026, ESTEVE PHARMACEUTICALS, S.A.); the spironolactone FDA label on DailyMed (effective November 28, 2025, Pfizer Laboratories Div Pfizer Inc).
What does the mitotane label say about spironolactone?
Mitotane label, drug interactionsDRUG INTERACTIONS Spironolactone: Avoid concomitant use with LYSODREN.
Source: FDA drug label (Lysodren), ESTEVE PHARMACEUTICALS, S.A., effective March 3, 2026 (SPL set 4046a224-8832-daa2-e063-6294a90a11d7), via openFDA; the full label on DailyMed
What does the spironolactone label say about mitotane?
Spironolactone label, drug interactionsAvoid concomitant use of ALDACTONE and mitotane ( 7.8 ).
Source: FDA drug label (Aldactone), Pfizer Laboratories Div Pfizer Inc, effective November 28, 2025 (SPL set 0fed2822-3a03-4b64-9857-c682fcd462bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mitotane | Spironolactone | |
|---|---|---|
| Labeled for | n/a | Heart failure, Edema (fluid retention), High blood pressure |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0426 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once