What the FDA labels say about taking them together
Midodrine and pseudoephedrine
Midodrine's FDA label of December 4, 2025 names pseudoephedrine in its drug interactions section; the pseudoephedrine label PlainMeds reads does not name midodrine. The midodrine label: “The risk of hypertension increases with concomitant administration of drugs that increase blood pressure.”
Check it at the source: the midodrine FDA label on DailyMed (effective December 4, 2025, Novugen Pharma (USA) LLC); the pseudoephedrine FDA label on DailyMed (effective October 30, 2025, L. Perrigo Company).
What does the midodrine label say about pseudoephedrine?
Midodrine label, drug interactionsThe risk of hypertension increases with concomitant administration of drugs that increase blood pressure (phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, or droxidopa).
Source: FDA drug label (Midodrine Hydrochloride), Novugen Pharma (USA) LLC, effective December 4, 2025 (SPL set 2bf011fe-d114-42a4-93e2-76a993a3ba34), via openFDA; the full label on DailyMed
What does the pseudoephedrine label say about midodrine?
Pseudoephedrine's label (effective October 30, 2025) does not name midodrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Good Sense Suphedrine 12 Hour), L. Perrigo Company, effective October 30, 2025 (SPL set 1de8a7f6-e7bb-437d-8794-c4b9f43b89c9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Midodrine | Pseudoephedrine | |
|---|---|---|
| Labeled for | n/a | Cough and cold |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.111 per tablet 5 mg tablet | $0.281 per tablet 120 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once