What the FDA labels say about taking them together
Midodrine and phenylephrine
Midodrine's FDA label of December 4, 2025 names phenylephrine in its drug interactions section; the phenylephrine labels PlainMeds reads (4) do not name midodrine. The midodrine label: “The risk of hypertension increases with concomitant administration of drugs that increase blood pressure.”
Check it at the source: the midodrine FDA label on DailyMed (effective December 4, 2025, Novugen Pharma (USA) LLC); the phenylephrine FDA label on DailyMed (effective August 19, 2026, Hikma Pharmaceuticals USA Inc.).
What does the midodrine label say about phenylephrine?
Midodrine label, drug interactionsThe risk of hypertension increases with concomitant administration of drugs that increase blood pressure (phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, or droxidopa).
Source: FDA drug label (Midodrine Hydrochloride), Novugen Pharma (USA) LLC, effective December 4, 2025 (SPL set 2bf011fe-d114-42a4-93e2-76a993a3ba34), via openFDA; the full label on DailyMed
What does the phenylephrine label say about midodrine?
Phenylephrine's label (effective August 19, 2026) and its 3 other brand-application labels do not name midodrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenylephrine Hydrochloride), Hikma Pharmaceuticals USA Inc., effective August 19, 2026 (SPL set e1a7ab4b-0afe-4463-a039-5be0323cf2f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Midodrine | Phenylephrine | |
|---|---|---|
| Labeled for | n/a | Cough and cold, Allergies |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.111 per tablet 5 mg tablet | $5.24 per mL 10% eye drop |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once