What the FDA labels say about taking them together
Midazolam and voxelotor
Voxelotor's FDA label of December 26, 2023 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name voxelotor. The voxelotor label: “Voxelotor on Other Drugs Voxelotor increased the systemic exposure of midazolam.”
Check it at the source: the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC); the voxelotor FDA label on DailyMed (effective December 26, 2023, Global Blood Therapeutics, Inc, A subsidiary of Pfizer Inc.).
What does the midazolam label say about voxelotor?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name voxelotor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
What does the voxelotor label say about midazolam?
Voxelotor label, drug interactionsVoxelotor on Other Drugs Voxelotor increased the systemic exposure of midazolam (a sensitive CYP3A4 substrate) [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (OXBRYTA), Global Blood Therapeutics, Inc, A subsidiary of Pfizer Inc., effective December 26, 2023 (SPL set 3c557fac-29ec-483f-b691-8a935d4decc3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Midazolam | Voxelotor | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.233 per mL 2 mg/2 mL vial | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once