What the FDA labels say about taking them together
Midazolam and telotristat
Telotristat's FDA label of August 6, 2026 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name telotristat. The telotristat label: “Concomitant use of Xermelo may decrease the efficacy of drugs that are CYP3A4 substrates (e.g., midazolam) by decreasing their systemic exposure.”
Check it at the source: the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC); the telotristat FDA label on DailyMed (effective August 6, 2026).
What does the midazolam label say about telotristat?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name telotristat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
What does the telotristat label say about midazolam?
Telotristat label, drug interactionsConcomitant use of Xermelo may decrease the efficacy of drugs that are CYP3A4 substrates (e.g., midazolam) by decreasing their systemic exposure.
Source: FDA drug label (Xermelo), TerSera Therapeutics LLC, effective August 6, 2026 (SPL set a4ac9d62-887c-4c8f-b04d-a5f31cec7c86), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Midazolam | Telotristat | |
|---|---|---|
| Labeled for | n/a | Diarrhea |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.233 per mL 2 mg/2 mL vial | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once