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What the FDA labels say about taking them together

Micafungin and sirolimus

Micafungin's FDA label of November 8, 2025 names sirolimus in its drug interactions section; the sirolimus labels PlainMeds reads (4) do not name micafungin. The micafungin label: “DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity, and dosage of sirolimus, itraconazole or nifedipine should be reduced, if necessary.”

Check it at the source: the micafungin FDA label on DailyMed (effective November 8, 2025, Sagent Pharmaceuticals); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).

What does the micafungin label say about sirolimus?

Micafungin label, drug interactions

DRUG INTERACTIONS Monitor for sirolimus, itraconazole or nifedipine toxicity, and dosage of sirolimus, itraconazole or nifedipine should be reduced, if necessary.

Source: FDA drug label (Micafungin), Sagent Pharmaceuticals, effective November 8, 2025 (SPL set 33e579c1-b315-44cb-a690-e2dd2cdf44ee), via openFDA; the full label on DailyMed

What does the sirolimus label say about micafungin?

Sirolimus's label (effective January 28, 2026) and its 3 other brand-application labels do not name micafungin in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

10Micafungin generic labelers
17Sirolimus generic labelers
MicafunginSirolimus
Labeled forFungal infectionsOrgan transplant rejection
Boxed warningNoYes
Pharmacy cost (NADAC)n/a$0.723 per tablet 1 mg tablet
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?