What the FDA labels say about taking them together
Mexiletine and riluzole
Riluzole's FDA label of July 10, 2020 names mexiletine in its drug interactions section; the mexiletine label PlainMeds reads does not name riluzole. The riluzole label: “The concomitant use of strong or moderate CYP1A2 inhibitors with riluzole may increase the risk of riluzole-associated adverse reactions.”
Check it at the source: the mexiletine FDA label on DailyMed (effective May 14, 2026, Macleods Pharmaceuticals Limited); the riluzole FDA label on DailyMed (effective July 10, 2020, Glenmark Pharmaceuticals Inc., USA).
What does the mexiletine label say about riluzole?
Mexiletine's label (effective May 14, 2026) does not name riluzole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mexiletine Hydrochloride), Macleods Pharmaceuticals Limited, effective May 14, 2026 (SPL set a61a07f6-0b48-4dcd-ad42-5d90f6e69ab1), via openFDA; the full label on DailyMed
What does the riluzole label say about mexiletine?
Riluzole label, drug interactionsThe concomitant use of strong or moderate CYP1A2 inhibitors (e.g., ciprofloxacin, enoxacin, fluvoxamine, methoxsalen, mexiletine, oral contraceptives, thiabendazole, vemurafenib, zileuton) with riluzole may increase the risk of riluzole-associated adverse reactions [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (riluzole), Glenmark Pharmaceuticals Inc., USA, effective July 10, 2020 (SPL set f1ce57e8-d3fe-422c-8724-3101c258898a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mexiletine | Riluzole | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.222 per capsule 150 mg capsule | $0.293 per tablet 50 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once