What the FDA labels say about taking them together
Metreleptin and theophylline
Metreleptin's FDA label of March 25, 2024 names theophylline in its drug interactions section; the theophylline label PlainMeds reads does not name metreleptin. The metreleptin label: “Upon initiation or discontinuation of MYALEPT, in patients being treated with these types of agents, therapeutic monitoring of effect (e.g., warfarin) or drug concentration should be performed and the individual dose of …”
Check it at the source: the metreleptin FDA label on DailyMed (effective March 25, 2024, Chiesi USA, Inc.); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).
What does the metreleptin label say about theophylline?
Metreleptin label, drug interactionsUpon initiation or discontinuation of MYALEPT, in patients being treated with these types of agents, therapeutic monitoring of effect (e.g., warfarin) or drug concentration (e.g., cyclosporine or theophylline) should be performed and the individual dose of the agent adjusted as needed.
Source: FDA drug label (Myalept), Chiesi USA, Inc., effective March 25, 2024 (SPL set d3b50bbd-140b-425c-b5ec-d4682aad62bc), via openFDA; the full label on DailyMed
What does the theophylline label say about metreleptin?
Theophylline's label (effective March 10, 2026) does not name metreleptin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metreleptin | Theophylline | |
|---|---|---|
| Labeled for | n/a | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.330 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once