What the FDA labels say about taking them together
Metoclopramide and succinylcholine
Metoclopramide's FDA label of May 18, 2026 names succinylcholine in its drug interactions section, and succinylcholine's label names metoclopramide too. The succinylcholine label: “… carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, terbutaline, and drugs that reduce plasma cholinesterase activity.”
Check it at the source: the metoclopramide FDA label on DailyMed (effective May 18, 2026, ANI Pharmaceuticals, Inc.); the succinylcholine FDA label on DailyMed (effective August 18, 2026, Hospira, Inc.).
What does the metoclopramide label say about succinylcholine?
Metoclopramide label, drug interactionsExamples Apomorphine, bromocriptine, cabergoline, levodopa, pramipexole, ropinirole, rotigotine Succinylcholine, Mivacurium Clinical Impact Metoclopramide inhibits plasma cholinesterase leading to enhanced neuromuscular blockade. Intervention Monitor for signs and symptoms of prolonged neuromuscular blockade.
Gimoti label (Evoke Pharma, Inc., February 20, 2026), drug interactionsExamples Apomorphine, bromocriptine, cabergoline, levodopa, pramipexole, ropinirole, rotigotine Succinylcholine, Mivacurium Clinical Impact Metoclopramide inhibits plasma cholinesterase leading to enhanced neuromuscular blockade.
Source: FDA drug label (Gimoti, NDA209388), Evoke Pharma, Inc., effective February 20, 2026 (SPL set 95269b1f-779c-4ca0-9f86-e74e677f9900), via openFDA
Source: FDA drug label (Metoclopramide), NDA017854 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective May 18, 2026 (SPL set 797aad80-0597-42f8-99d5-39de180c3b5a), via openFDA; the full label on DailyMed
What does the succinylcholine label say about metoclopramide?
Succinylcholine label, drug interactionsDRUG INTERACTIONS Drugs that May Enhance the Neuromuscular Blocking Action of Succinylcholine: promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, terbutaline, and drugs that reduce plasma cholinesterase activity.
Source: FDA drug label (QUELICIN), Hospira, Inc., effective August 18, 2026 (SPL set fb08161e-7711-406d-e7b3-ea4515c07983), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metoclopramide | Succinylcholine | |
|---|---|---|
| Labeled for | Acid reflux and ulcers, Nausea and vomiting | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0439 per tablet 10 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once