What the FDA labels say about taking them together
Methyltestosterone and testosterone
Methyltestosterone's FDA label of May 31, 2025 names testosterone in its drug interactions section, and testosterone's label names methyltestosterone too. The methyltestosterone label: “Anticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants.”
Check it at the source: the methyltestosterone FDA label on DailyMed (effective May 31, 2025, Amneal Pharmaceuticals of New York LLC); the testosterone FDA label on DailyMed (effective July 25, 2025, Azurity Pharmaceuticals, Inc.).
What does the methyltestosterone label say about testosterone?
Methyltestosterone label, drug interactionsAnticoagulants: C-17 substituted derivatives of testosterone, such as methandrostenolone, have been reported to decrease the anticoagulant requirements of patients receiving oral anticoagulants.
Methyltestosterone label, warningsTo date, epidemiologic studies and randomized controlled trials have been inconclusive for determining the risk of major adverse cardiovascular events (MACE), such as non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death, with the use of testosterone compared to non-use.
Source: FDA drug label (MethylTESTOSTERone), ANDA204851 (Impax Labs Inc), as published by Amneal Pharmaceuticals of New York LLC, effective May 31, 2025 (SPL set 9bed4886-fcd0-4056-be8d-5bb4d15081ce), via openFDA; the full label on DailyMed
What does the testosterone label say about methyltestosterone?
Testosterone label, warnings and precautionsProlonged use of high doses of orally active 17-alpha-alkyl androgens (e.g., methyltestosterone) has been associated with serious hepatic adverse effects (peliosis hepatis, hepatic neoplasms, cholestatic hepatitis, and jaundice).
Source: FDA drug label (AZMIRO), Azurity Pharmaceuticals, Inc., effective July 25, 2025 (SPL set 235b5625-570d-3fba-e063-6394a90aa2d1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methyltestosterone | Testosterone | |
|---|---|---|
| Labeled for | Breast cancer | Breast cancer |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $11.39 per mL 200 mg/mL |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once