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What the FDA labels say about taking them together

Methylprednisolone and ublituximab

Ublituximab's FDA label of February 19, 2026 names methylprednisolone in its warnings and precautions section; the methylprednisolone labels PlainMeds reads (3) do not name ublituximab. The ublituximab label: “In Studies 1 and 2, patients received methylprednisolone (or an equivalent steroid), an antihistamine, and possibly other pre-medication (i.e., acetaminophen) to reduce the risk of infusion reactions prior to each …”

Check it at the source: the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.); the ublituximab FDA label on DailyMed (effective February 19, 2026).

What does the methylprednisolone label say about ublituximab?

Methylprednisolone's label (effective June 22, 2026) and its 2 other brand-application labels do not name ublituximab in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed

What does the ublituximab label say about methylprednisolone?

Ublituximab label, warnings and precautions

In Studies 1 and 2 [see Clinical Studies (14) ], patients received methylprednisolone (or an equivalent steroid), an antihistamine, and possibly other pre-medication (i.e., acetaminophen) to reduce the risk of infusion reactions prior to each infusion.

Source: FDA drug label (BRIUMVI), TG Therapeutics, Inc., effective February 19, 2026 (SPL set 3a77cd8c-811b-407c-9140-d0c5c26435c2), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

35Methylprednisolone generic labelers
0Ublituximab generic labelers
MethylprednisoloneUblituximab
Labeled forOsteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), AnemiaMultiple sclerosis
Boxed warningNoNo
Pharmacy cost (NADAC)$0.121 per tablet 4 mg tabletn/a
Shortage nowIn shortageNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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