What the FDA labels say about taking them together
Methylprednisolone and rifampin
Methylprednisolone's FDA label of June 22, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name methylprednisolone. The methylprednisolone label: “Hepatic Enzyme Inducers: Drugs which induce cytochrome P450 3A4 enzyme activity may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased.”
Check it at the source: the methylprednisolone FDA label on DailyMed (effective June 22, 2026, Mylan Pharmaceuticals Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the methylprednisolone label say about rifampin?
Methylprednisolone label, drug interactionsDrugs that induce hepatic enzymes such as phenobarbital, phenytoin, and rifampin may increase the clearance of methylprednisolone and may require increases in methylprednisolone dose to achieve the desired response.
Solu-Medrol label (Pharmacia & Upjohn Company LLC, December 2, 2025), drug interactionsHepatic Enzyme Inducers (e.g., barbiturates, phenytoin, carbamazepine, rifampin): Drugs which induce cytochrome P450 3A4 enzyme activity may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased.
Source: FDA drug label (Solu-Medrol, NDA011856), Pharmacia & Upjohn Company LLC, effective December 2, 2025 (SPL set cd99be87-c8d9-48d6-a8e5-e081052e3f19), via openFDA
Source: FDA drug label (Methylprednisolone), NDA011153 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective June 22, 2026 (SPL set 22dd75d6-f89a-44f7-8ca6-b64c4e9806dd), via openFDA; the full label on DailyMed
What does the rifampin label say about methylprednisolone?
Rifampin's label (effective February 11, 2026) does not name methylprednisolone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methylprednisolone | Rifampin | |
|---|---|---|
| Labeled for | Osteoarthritis, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Asthma, Eczema (atopic dermatitis), Anemia | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.121 per tablet 4 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | In shortage | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once