What the FDA labels say about taking them together
Methotrexate and teriflunomide
Teriflunomide's FDA label of February 20, 2026 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name teriflunomide. The teriflunomide label: “In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates may be increased.”
Check it at the source: the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).
What does the methotrexate label say about teriflunomide?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
What does the teriflunomide label say about methotrexate?
Teriflunomide label, drug interactionsIn patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased.
Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methotrexate | Teriflunomide | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer | Multiple sclerosis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.158 per tablet 2.5 mg tablet | $0.233 per tablet 14 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once