What the FDA labels say about taking them together
Methotrexate and tafamidis
Tafamidis's FDA label of May 12, 2026 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name tafamidis. The tafamidis label: “Coadministration of tafamidis and drugs that are BCRP substrates may increase the exposure of substrates of this transporter and the risk of the substrate-related toxicities.”
Check it at the source: the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.); the tafamidis FDA label on DailyMed (effective May 12, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the methotrexate label say about tafamidis?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name tafamidis in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
What does the tafamidis label say about methotrexate?
Tafamidis label, drug interactionsCoadministration of tafamidis and drugs that are BCRP substrates may increase the exposure of substrates of this transporter (e.g., methotrexate, rosuvastatin, imatinib) and the risk of the substrate-related toxicities.
Source: FDA drug label (Vyndaqel), NDA211996 (Foldrx Pharms), as published by Pfizer Laboratories Div Pfizer Inc, effective May 12, 2026 (SPL set 1b4121ee-a733-4456-a917-be2603477839), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methotrexate | Tafamidis | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.158 per tablet 2.5 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once