What the FDA labels say about taking them together
Methotrexate and salicylic acid
Salicylic acid's FDA label of October 22, 2024 names methotrexate in its drug interactions (prescription label) section; the methotrexate labels PlainMeds reads (4) do not name salicylic acid. The salicylic acid label: “Sulfonylureas Hypoglycemia potentiated Methotrexate Decreases tubular reabsorption; clinical toxicity from methotrexate can result Oral Anticoagulant Increased bleeding II.”
Check it at the source: the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.); the salicylic acid FDA label on DailyMed (effective October 22, 2024).
What does the methotrexate label say about salicylic acid?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name salicylic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
What does the salicylic acid label say about methotrexate?
Salicylic acid label, drug interactions (prescription label)Sulfonylureas Hypoglycemia potentiated Methotrexate Decreases tubular reabsorption; clinical toxicity from methotrexate can result Oral Anticoagulant Increased bleeding II.
Source: FDA drug label (bareMinerals Blemish Rescue Skin-Clearing Loose Foundation Fair 1C), Orveon Global US LLC, effective October 22, 2024 (SPL set 139e2d26-76de-4ad3-a6e6-7465bf5987ad), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methotrexate | Salicylic acid | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer | Acne, Pain, Psoriasis |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.158 per tablet 2.5 mg tablet | $0.102 per patch Callus removers patch |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once