What the FDA labels say about taking them together
Methotrexate and pivmecillinam
Pivmecillinam's FDA label of October 10, 2025 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name pivmecillinam. The pivmecillinam label: “Clearance of methotrexate from the body can be reduced by concurrent use of drugs in the penicillin class, including PIVYA. Where possible, consider alternative therapy.”
Check it at the source: the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.); the pivmecillinam FDA label on DailyMed (effective October 10, 2025, Alembic Pharmaceuticals Inc.).
What does the methotrexate label say about pivmecillinam?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name pivmecillinam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
What does the pivmecillinam label say about methotrexate?
Pivmecillinam label, drug interactionsClearance of methotrexate from the body can be reduced by concurrent use of drugs in the penicillin class, including PIVYA. Where possible, consider alternative therapy.
Source: FDA drug label (PIVYA), Alembic Pharmaceuticals Inc., effective October 10, 2025 (SPL set 440a5f17-ab11-0fc8-e063-6394a90a58e9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methotrexate | Pivmecillinam | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer | Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.158 per tablet 2.5 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once