What the FDA labels say about taking them together
Methotrexate and multiple vitamins
Multiple vitamins's FDA label of November 20, 2024 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name multiple vitamins. The multiple vitamins label: “Methotrexate: Folic acid may decrease response to methotrexate Effects of other drugs on INFUVITE ADULT:”
Check it at the source: the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.); the multiple vitamins FDA label on DailyMed (effective November 20, 2024).
What does the methotrexate label say about multiple vitamins?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name multiple vitamins in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
What does the multiple vitamins label say about methotrexate?
Multiple vitamins label, drug interactionsMethotrexate: Folic acid may decrease response to methotrexate ( 7.1 ) Effects of other drugs on INFUVITE PEDIATRIC:
Source: FDA drug label (Infuvite Adult, NDA021163), Sandoz Inc, effective November 6, 2024 (SPL set 14c7bfc5-07e8-400f-b8ff-5e4794dd2805), via openFDA
Source: FDA drug label (Infuvite Pediatric), Sandoz Inc, effective November 20, 2024 (SPL set 6d06546e-8b0a-4490-82d9-397bd902a044), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methotrexate | Multiple vitamins | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.158 per tablet 2.5 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once