What the FDA labels say about taking them together
Methocarbamol and pyridostigmine
Methocarbamol's FDA label of March 17, 2026 names pyridostigmine in its drug interactions section; the pyridostigmine labels PlainMeds reads (4) do not name methocarbamol.
Check it at the source: the methocarbamol FDA label on DailyMed (effective March 17, 2026, Oxford Pharmaceuticals, LLC); the pyridostigmine FDA label on DailyMed (effective December 2, 2020, Bausch Health US, LLC).
What does the methocarbamol label say about pyridostigmine?
Methocarbamol label, drug interactionsMethocarbamol may inhibit the effect of pyridostigmine bromide.
Source: FDA drug label (Atmeksi, NDA219843), Rosemont Pharmaceuticals LLC, effective March 13, 2026 (SPL set 62de7345-613b-4838-96e5-aceca3cea6b2), via openFDA
Source: FDA drug label (Methocarbamol), Oxford Pharmaceuticals, LLC, effective March 17, 2026 (SPL set 06dc72a6-ef3a-425a-9194-a9d228093cc4), via openFDA; the full label on DailyMed
What does the pyridostigmine label say about methocarbamol?
Pyridostigmine's label (effective December 2, 2020) and its 3 other brand-application labels do not name methocarbamol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mestinon), Bausch Health US, LLC, effective December 2, 2020 (SPL set a851795e-b7a8-40c3-9922-5e79d3eb4d92), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methocarbamol | Pyridostigmine | |
|---|---|---|
| Labeled for | Muscle spasms and spasticity | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0395 per tablet 500 mg tablet | $0.249 per tablet 60 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once