What the FDA labels say about taking them together
Methamphetamine and tramadol
Methamphetamine's FDA label of September 30, 2024 names tramadol in its warnings and precautions section; the tramadol labels PlainMeds reads (3) do not name methamphetamine. The methamphetamine label: “… inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort.”
Check it at the source: the methamphetamine FDA label on DailyMed (effective September 30, 2024, Hikma Pharmaceuticals USA Inc.); the tramadol FDA label on DailyMed (effective March 5, 2026, Lupin Pharmaceuticals, Inc.).
What does the methamphetamine label say about tramadol?
Methamphetamine label, warnings and precautionsSerotonin syndrome, a potentially life-threatening reaction, may occur when amphetamines are used in combination with other drugs that affect the serotonergic neurotransmitter systems such as monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort [see Drug Interactions ( 7.1 )].
Source: FDA drug label (Methamphetamine Hydrochloride), Hikma Pharmaceuticals USA Inc., effective September 30, 2024 (SPL set 90c02ac6-e5e2-4c97-8c68-81e4e389a195), via openFDA; the full label on DailyMed
What does the tramadol label say about methamphetamine?
Tramadol's label (effective March 5, 2026) and its 2 other brand-application labels do not name methamphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TRAMADOL HYDROCHLORIDE), Lupin Pharmaceuticals, Inc., effective March 5, 2026 (SPL set 46bb9ae6-3ee8-463c-badb-c7a45a89b84b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methamphetamine | Tramadol | |
|---|---|---|
| Labeled for | ADHD | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $5.10 per tablet 5 mg tablet | $0.0248 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once