What the FDA labels say about taking them together
Methamphetamine and methylene blue
Methamphetamine's FDA label of September 30, 2024 names methylene blue in its contraindications section; the methylene blue label PlainMeds reads does not name methamphetamine. The methamphetamine label: “• taking monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of treatment with an MAOIs, because of the risk of hypertensive crisis.”
Check it at the source: the methamphetamine FDA label on DailyMed (effective September 30, 2024, Hikma Pharmaceuticals USA Inc.); the methylene blue FDA label on DailyMed (effective May 28, 2025, American Regent, Inc.).
What does the methamphetamine label say about methylene blue?
Methamphetamine label, contraindications• taking monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of treatment with an MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of the risk of hypertensive crisis [see Drug Interactions ( 7.1 )].
Source: FDA drug label (Methamphetamine Hydrochloride), Hikma Pharmaceuticals USA Inc., effective September 30, 2024 (SPL set 90c02ac6-e5e2-4c97-8c68-81e4e389a195), via openFDA; the full label on DailyMed
What does the methylene blue label say about methamphetamine?
Methylene blue's label (effective May 28, 2025) does not name methamphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PROVAYBLUE), NDA204630 (Provepharm Sas), as published by American Regent, Inc., effective May 28, 2025 (SPL set 4f6848e5-35ed-4046-b13c-3032b5ba3232), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methamphetamine | Methylene blue | |
|---|---|---|
| Labeled for | ADHD | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $5.10 per tablet 5 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once