What the FDA labels say about taking them together
Metformin and tafenoquine
Tafenoquine's FDA label of January 10, 2025 names metformin in its drug interactions section; the metformin labels PlainMeds reads (3) do not name tafenoquine. The tafenoquine label: “Avoid coadministration of ARAKODA with OCT2 and MATE substrates.”
Check it at the source: the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd); the tafenoquine FDA label on DailyMed (effective January 10, 2025, 60 Degrees Pharmaceuticals, INC.).
What does the metformin label say about tafenoquine?
Metformin's label (effective September 3, 2026) and its 2 other brand-application labels do not name tafenoquine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
What does the tafenoquine label say about metformin?
Tafenoquine label, drug interactionsAvoid coadministration of ARAKODA with OCT2 and MATE substrates (e.g., dofetilide, metformin).
Source: FDA drug label (Krintafel, NDA210795), GlaxoSmithKline LLC, effective August 2, 2023 (SPL set 5cf989d5-36f5-4561-a30b-9fcb9deb6b6a), via openFDA
Source: FDA drug label (Arakoda), 60 Degrees Pharmaceuticals, INC., effective January 10, 2025 (SPL set 299e49d8-470f-4779-a010-4a1ee0e0c6cd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metformin | Tafenoquine | |
|---|---|---|
| Labeled for | Type 2 diabetes | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0145 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once