What the FDA labels say about taking them together
Metformin and risdiplam
Risdiplam's FDA label of February 19, 2026 names metformin in its drug interactions section; the metformin labels PlainMeds reads (3) do not name risdiplam. The risdiplam label: “Substrates of Multidrug and Toxin Extrusion (MATE) Protein Transporters Based on in vitro data, EVRYSDI may increase plasma concentrations of drugs eliminated via MATE1 or MATE2-K, such as metformin.”
Check it at the source: the metformin FDA label on DailyMed (effective September 3, 2026, Granules India Ltd); the risdiplam FDA label on DailyMed (effective February 19, 2026, Genentech, Inc.).
What does the metformin label say about risdiplam?
Metformin's label (effective September 3, 2026) and its 2 other brand-application labels do not name risdiplam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (METFORMIN HYDROCHLORIDE), Granules India Ltd, effective September 3, 2026 (SPL set 73197cb5-3e23-4ac0-b189-f9bc848bce66), via openFDA; the full label on DailyMed
What does the risdiplam label say about metformin?
Risdiplam label, drug interactionsSubstrates of Multidrug and Toxin Extrusion (MATE) Protein Transporters Based on in vitro data, EVRYSDI may increase plasma concentrations of drugs eliminated via MATE1 or MATE2-K [see Clinical Pharmacology (12.3) ], such as metformin.
Source: FDA drug label (EVRYSDI), Genentech, Inc., effective February 19, 2026 (SPL set eceb9a99-7191-4be5-87c3-0102707cf98e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metformin | Risdiplam | |
|---|---|---|
| Labeled for | Type 2 diabetes | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0145 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once