What the FDA labels say about taking them together
Meloxicam and sodium polystyrene sulfonate
Meloxicam's FDA label (Meloxicam) of May 29, 2026 names sodium polystyrene sulfonate in its drug interactions section; the sodium polystyrene sulfonate label PlainMeds reads does not name meloxicam. The meloxicam label: “Cases of intestinal necrosis (possibly fatal) have been described in patients who received concomitant sorbitol and sodium polystyrene sulfonate. …”
Check it at the source: the meloxicam FDA label on DailyMed (effective January 29, 2026, PD-Rx Pharmaceuticals, Inc.); the sodium polystyrene sulfonate FDA label on DailyMed (effective November 29, 2023, Epic Pharma, LLC).
What does the meloxicam label say about sodium polystyrene sulfonate?
Meloxicam label (Emerald Therapeutics, LLC, May 29, 2026), drug interactionsSodium Polystyrene Sulfonate Clinical Impact: Cases of intestinal necrosis (possibly fatal) have been described in patients who received concomitant sorbitol and sodium polystyrene sulfonate. Due to the presence of sorbitol in meloxicam oral suspension, use with sodium polystyrene sulfonate is not recommended. Intervention: The concomitant use of meloxicam oral suspension with sodium polystyrene sulfonate is not recommended.
Source: FDA drug label (Meloxicam, NDA021530), Emerald Therapeutics, LLC, effective May 29, 2026 (SPL set 55af77dd-2abc-49a6-990c-399d5a5e7a91), via openFDA
Source: FDA drug label (MELOXICAM), PD-Rx Pharmaceuticals, Inc., effective January 29, 2026 (SPL set 19c13159-71f1-2427-e063-6394a90ad44e), via openFDA; the full label on DailyMed
What does the sodium polystyrene sulfonate label say about meloxicam?
Sodium polystyrene sulfonate's label (effective November 29, 2023) does not name meloxicam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sodium Polystyrene Sulfonate), Epic Pharma, LLC, effective November 29, 2023 (SPL set 61cc890b-eb3d-494c-ae45-629a27e721ce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Meloxicam | Sodium polystyrene sulfonate | |
|---|---|---|
| Labeled for | Osteoarthritis, Rheumatoid arthritis, Pain | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0166 per tablet 7.5 mg tablet | $0.155 per gram Sodium polystyrene sulf powder |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once