Meloxicam and Cyclosporine Interaction
Drug interaction information between Meloxicam and Cyclosporine.
Meloxicam and Cyclosporine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Meloxicam and Cyclosporine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using meloxicam with cyclosporine can increase the risk of harm to your kidneys. This combination makes it harder for the kidneys to work properly.
FDA Label Information
Cyclosporine Clinical Impact: Concomitant use of meloxicam and cyclosporine may increase cyclosporine's nephrotoxicity. Intervention: During concomitant use of meloxicam and cyclosporine, monitor patients for signs of worsening renal function.
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Meloxicam + Cyclosporine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cyclosporine has 89 labeled pairs on file vs Meloxicam's 17. In the minor band specifically: Meloxicam has 15 (also Furosemide, Aspirin, Propranolol, Warfarin); Cyclosporine has 60 (also Adalimumab, Amiodarone, Amlodipine, Anidulafungin).
What mechanism field is on file for Meloxicam and Cyclosporine?
Using meloxicam with cyclosporine can increase the risk of harm to your kidneys. This combination makes it harder for the kidneys to work properly.
Cyclosporine carries more major-labeled pairs than Meloxicam
SPL source-record counts only. This page's band is minor · classes on file: Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Cyclosporine (Calcineurin Inhibitor (Immunosuppressant)).
Cyclosporine has 5 major-labeled pairs vs Meloxicam's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Meloxicam
- Furosemide
- Aspirin
- Propranolol
- Warfarin
5 major · 24 moderate · 60 minor · 89 total
- Other minor peers for Cyclosporine
- Adalimumab
- Amiodarone
- Amlodipine
- Anidulafungin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.