What the FDA labels say about taking them together
Mefloquine and quinidine
Mefloquine's FDA label of November 18, 2024 names quinidine in its contraindications section; the quinidine label PlainMeds reads does not name mefloquine. The mefloquine label: “CONTRAINDICATIONS Use of mefloquine hydrochloride tablets is contraindicated in patients with a known hypersensitivity to mefloquine or related compounds or to any of the excipients contained in the formulation.”
Check it at the source: the mefloquine FDA label on DailyMed (effective November 18, 2024, Chartwell RX, LLC); the quinidine FDA label on DailyMed (effective February 1, 2018, Sun Pharmaceutical Industries, Inc.).
What does the mefloquine label say about quinidine?
Mefloquine label, contraindicationsCONTRAINDICATIONS Use of mefloquine hydrochloride tablets is contraindicated in patients with a known hypersensitivity to mefloquine or related compounds (eg, quinine and quinidine) or to any of the excipients contained in the formulation.
Source: FDA drug label (Mefloquine Hydrochloride), Chartwell RX, LLC, effective November 18, 2024 (SPL set b884d22b-aae7-4f14-9a04-ae4029a229f0), via openFDA; the full label on DailyMed
What does the quinidine label say about mefloquine?
Quinidine's label (effective February 1, 2018) does not name mefloquine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Quinidine Gluconate), Sun Pharmaceutical Industries, Inc., effective February 1, 2018 (SPL set 5023f053-fcc4-4c2c-aa59-9ec198ad185e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mefloquine | Quinidine | |
|---|---|---|
| Labeled for | n/a | Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $3.97 per tablet 250 mg tablet | $4.92 per tablet 324 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once