What the FDA labels say about taking them together
Mefloquine and pimozide
Pimozide's FDA label of August 12, 2026 names mefloquine in its drug interactions section; the mefloquine label PlainMeds reads does not name pimozide. The pimozide label: “… chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, or other drugs …”
Check it at the source: the mefloquine FDA label on DailyMed (effective November 18, 2024, Chartwell RX, LLC); the pimozide FDA label on DailyMed (effective August 12, 2026, Par Health USA, LLC).
What does the mefloquine label say about pimozide?
Mefloquine's label (effective November 18, 2024) does not name pimozide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mefloquine Hydrochloride), Chartwell RX, LLC, effective November 18, 2024 (SPL set b884d22b-aae7-4f14-9a04-ae4029a229f0), via openFDA; the full label on DailyMed
What does the pimozide label say about mefloquine?
Pimozide label, drug interactionsAccordingly, pimozide should not be given with dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol, tacrolimus, ziprasidone, or other drugs that have demonstrated QT prolongation as one of their pharmacodynamic effects.
Source: FDA drug label (Pimozide), Par Health USA, LLC, effective August 12, 2026 (SPL set 70b079e2-a1f7-4a93-8685-d60a4d7c1280), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mefloquine | Pimozide | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $3.97 per tablet 250 mg tablet | $1.23 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once