What the FDA labels say about taking them together
Meclofenamate and methotrexate
Meclofenamate's FDA label of April 15, 2026 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name meclofenamate.
Check it at the source: the meclofenamate FDA label on DailyMed (effective April 15, 2026, Mylan Pharmaceuticals Inc.); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the meclofenamate label say about methotrexate?
Meclofenamate label, drug interactionsMethotrexate NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices.
Source: FDA drug label (Meclofenamate Sodium), Mylan Pharmaceuticals Inc., effective April 15, 2026 (SPL set 96f19af4-de8f-4fd7-90d8-55fe6ebdd81d), via openFDA; the full label on DailyMed
What does the methotrexate label say about meclofenamate?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name meclofenamate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Meclofenamate | Methotrexate | |
|---|---|---|
| Labeled for | Fever, Pain, Rheumatoid arthritis, Osteoarthritis | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once