What the FDA labels say about taking them together
Magnesium sulfate and propofol
Magnesium sulfate's FDA label (Magnesium Sulfate In Dextrose) of August 24, 2026 names propofol in its drug interactions section; the propofol label PlainMeds reads does not name magnesium sulfate.
Check it at the source: the magnesium sulfate FDA label on DailyMed (effective August 24, 2026, Hospira, Inc.); the propofol FDA label on DailyMed (effective September 11, 2025, Fresenius Kabi USA, LLC).
What does the magnesium sulfate label say about propofol?
Magnesium Sulfate In Dextrose label (Hospira, Inc., August 24, 2026), drug interactionsNarcotics and/or Propofol Clinical Impact: • Potentiation and prolongation of analgesia and CNS depression is possible with the concomitant use of Magnesium Sulfate in 5% Dextrose Injection with narcotics and/or propofol. The potential for magnesium sulfate to affect other CNS depressants is unknown. … Intervention: • Monitor the depth of CNS depression frequently using a reliable instrument. • Adjust the narcotic and/or propofol dosage accordingly to maintain the desired level of analgesia and sedation. Examples: • Narcotics and propofol
Source: FDA drug label (Magnesium Sulfate In Dextrose, NDA020488), Hospira, Inc., effective August 24, 2026 (SPL set 03ebeabb-8386-4af4-3086-bdf3c3fc4a5a), via openFDA
Source: FDA drug label (Magnesium Sulfate in Water), Hospira, Inc., effective August 24, 2026 (SPL set 22ca78b4-f5a3-4144-cf89-5f633acf1e6d), via openFDA; the full label on DailyMed
What does the propofol label say about magnesium sulfate?
Propofol's label (effective September 11, 2025) does not name magnesium sulfate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Diprivan), Fresenius Kabi USA, LLC, effective September 11, 2025 (SPL set e3105799-a4b6-f3f4-e6e2-b2b29bbdb538), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Magnesium sulfate | Propofol | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Constipation, Pain | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0039 per gram Epsom salt | $0.171 per mL 200 mg/20 mL vial |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once