What the FDA labels say about taking them together
Lurasidone and nafcillin
Lurasidone's FDA label of January 31, 2025 names nafcillin in its drug interactions section; the nafcillin labels PlainMeds reads (2) do not name lurasidone. The lurasidone label: “Concomitant use of LATUDA with moderate CYP3A4 inducers decreased the exposure of lurasidone compared to the use of LATUDA alone.”
Check it at the source: the lurasidone FDA label on DailyMed (effective January 31, 2025, Sumitomo Pharma America, Inc.); the nafcillin FDA label on DailyMed (effective March 9, 2026, ONESOURCE SPECIALTY PHARMA LIMITED).
What does the lurasidone label say about nafcillin?
Lurasidone label, drug interactionsModerate CYP3A4 Inducers Clinical Impact: Concomitant use of LATUDA with moderate CYP3A4 inducers decreased the exposure of lurasidone compared to the use of LATUDA alone. Intervention: LATUDA dose should be increased when used concomitantly with moderate inducers of CYP3A4 [see Dosage and Administration ()]. Examples: Bosentan, efavirenz, etravirine, modafinil, nafcillin
Source: FDA drug label (Latuda), NDA200603 (Sunovion Pharms Inc), as published by Sumitomo Pharma America, Inc., effective January 31, 2025 (SPL set afad3051-9df2-4c54-9684-e8262a133af8), via openFDA; the full label on DailyMed
What does the nafcillin label say about lurasidone?
Nafcillin's label (effective March 9, 2026) and its 1 other brand-application label do not name lurasidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (NAFCILLIN SODIUM), ONESOURCE SPECIALTY PHARMA LIMITED, effective March 9, 2026 (SPL set 4b3b8e52-df96-4886-e063-6294a90ac63f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lurasidone | Nafcillin | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.142 per tablet 20 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once