What the FDA labels say about taking them together
Lurasidone and modafinil
Lurasidone's FDA label of January 31, 2025 names modafinil in its drug interactions section; the modafinil label PlainMeds reads does not name lurasidone. The lurasidone label: “Concomitant use of LATUDA with moderate CYP3A4 inducers decreased the exposure of lurasidone compared to the use of LATUDA alone.”
Check it at the source: the lurasidone FDA label on DailyMed (effective January 31, 2025, Sumitomo Pharma America, Inc.); the modafinil FDA label on DailyMed (effective October 16, 2025, Golden State Medical Supply, Inc.).
What does the lurasidone label say about modafinil?
Lurasidone label, drug interactionsModerate CYP3A4 Inducers Clinical Impact: Concomitant use of LATUDA with moderate CYP3A4 inducers decreased the exposure of lurasidone compared to the use of LATUDA alone. Intervention: LATUDA dose should be increased when used concomitantly with moderate inducers of CYP3A4 [see Dosage and Administration ()]. Examples: Bosentan, efavirenz, etravirine, modafinil, nafcillin
Source: FDA drug label (Latuda), NDA200603 (Sunovion Pharms Inc), as published by Sumitomo Pharma America, Inc., effective January 31, 2025 (SPL set afad3051-9df2-4c54-9684-e8262a133af8), via openFDA; the full label on DailyMed
What does the modafinil label say about lurasidone?
Modafinil's label (effective October 16, 2025) does not name lurasidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Provigil), NDA020717 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective October 16, 2025 (SPL set 3b8d1c32-dac9-50e6-e063-6394a90aa5a5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lurasidone | Modafinil | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.142 per tablet 20 mg tablet | $0.344 per tablet 200 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once