What the FDA labels say about taking them together
Lubiprostone and methadone
Lubiprostone's FDA label of July 28, 2026 names methadone in its drug interactions section; the methadone labels PlainMeds reads (4) do not name lubiprostone. The lubiprostone label: “DRUG INTERACTIONS 7.1 Methadone Diphenylheptane opioids (e.g., methadone) have been shown in nonclinical studies to dose-dependently reduce the activation of ClC-2 by lubiprostone in the gastrointestinal tract.”
Check it at the source: the lubiprostone FDA label on DailyMed (effective July 28, 2026, Golden State Medical Supply, Inc.); the methadone FDA label on DailyMed (effective December 8, 2025, Epic Pharma, LLC).
What does the lubiprostone label say about methadone?
Lubiprostone label, drug interactionsDRUG INTERACTIONS 7.1 Methadone Diphenylheptane opioids (e.g., methadone) have been shown in nonclinical studies to dose-dependently reduce the activation of ClC-2 by lubiprostone in the gastrointestinal tract.
Source: FDA drug label (Lubiprostone), NDA021908 (Sucampo Pharma Llc), as published by Golden State Medical Supply, Inc., effective July 28, 2026 (SPL set f4d506e0-1322-4fc4-e053-2995a90ac880), via openFDA; the full label on DailyMed
What does the methadone label say about lubiprostone?
Methadone's label (effective December 8, 2025) and its 3 other brand-application labels do not name lubiprostone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methadone Hydrochloride), Epic Pharma, LLC, effective December 8, 2025 (SPL set 6da7501b-b881-4bc7-891a-74214a00a3ac), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lubiprostone | Methadone | |
|---|---|---|
| Labeled for | Constipation, Irritable bowel syndrome | Pain, Opioid use disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.651 per capsule 24 mcg capsule | $0.177 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once