What the FDA labels say about taking them together
Lovastatin and ranolazine
Lovastatin's FDA label of May 6, 2026 names ranolazine in its warnings section, and ranolazine's label names lovastatin too. The ranolazine label: “Doses of other sensitive CYP3A substrates (e.g., lovastatin) and CYP3A substrates with narrow therapeutic range may need to be reduced with ranolazine.”
Check it at the source: the lovastatin FDA label on DailyMed (effective May 6, 2026, Lupin Pharmaceuticals, Inc.); the ranolazine FDA label on DailyMed (effective January 23, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the lovastatin label say about ranolazine?
Lovastatin label, warningsRanolazine The risk of myopathy, including rhabdomyolysis, may be increased by concomitant administration of ranolazine.
Source: FDA drug label (Lovastatin), Lupin Pharmaceuticals, Inc., effective May 6, 2026 (SPL set df7ddf4f-d569-431e-81f1-9129d7043150), via openFDA; the full label on DailyMed
What does the ranolazine label say about lovastatin?
Ranolazine label, drug interactionsDoses of other sensitive CYP3A substrates (e.g., lovastatin) and CYP3A substrates with narrow therapeutic range (e.g., cyclosporine, tacrolimus, sirolimus) may need to be reduced with ranolazine.
Source: FDA drug label (Aspruzyo Sprinkle, NDA216018), SUN PHARMACEUTICAL INDUSTRIES, INC., effective January 29, 2025 (SPL set dd9f81e4-50da-4551-aed5-559d304df42e), via openFDA
Source: FDA drug label (Ranolazine), Glenmark Pharmaceuticals Inc., USA, effective January 23, 2026 (SPL set 0cf58732-c242-49b0-8e3f-248778b4458d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lovastatin | Ranolazine | |
|---|---|---|
| Labeled for | High cholesterol, Heart attack and coronary artery disease | Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0436 per tablet 20 mg tablet | $0.165 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once