What the FDA labels say about taking them together
Lorazepam and pyrimethamine
Pyrimethamine's FDA label of December 7, 2023 names lorazepam in its drug interactions section; the lorazepam labels PlainMeds reads (3) do not name pyrimethamine.
Check it at the source: the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC); the pyrimethamine FDA label on DailyMed (effective December 7, 2023, TILDE Sciences LLC).
What does the lorazepam label say about pyrimethamine?
Lorazepam's label (effective July 9, 2025) and its 2 other brand-application labels do not name pyrimethamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
What does the pyrimethamine label say about lorazepam?
Pyrimethamine label, drug interactionsMild hepatotoxicity has been reported in some patients when lorazepam and pyrimethamine were administered concomitantly.
Source: FDA drug label (Daraprim), TILDE Sciences LLC, effective December 7, 2023 (SPL set f634f34b-0952-4dd3-9da3-f84b6ab823de), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lorazepam | Pyrimethamine | |
|---|---|---|
| Labeled for | Anxiety | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0344 per tablet 0.5 mg tablet | $137.01 per tablet 25 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once