What the FDA labels say about taking them together
Lorazepam and norethindrone
Lorazepam's FDA label (Lorazepam) of April 10, 2024 names norethindrone in its drug interactions section; the norethindrone labels PlainMeds reads (2) do not name lorazepam. The lorazepam label: “LORAZEPAM-ORAL CONTRACEPTIVE STEROIDS INTERACTION Coadministration of lorazepam (2 mg intravenously) with oral contraceptive steroids to healthy females (n=7) was associated with a 55% decrease in half-life, a 50% …”
Check it at the source: the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC); the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the lorazepam label say about norethindrone?
Lorazepam label (Hikma Pharmaceuticals USA Inc., April 10, 2024), drug interactionsLORAZEPAM-ORAL CONTRACEPTIVE STEROIDS INTERACTION Coadministration of lorazepam (2 mg intravenously) with oral contraceptive steroids (norethindrone acetate, 1 mg, and ethinyl estradiol, 50 μg, for at least 6 months) to healthy females (n=7) was associated with a 55% decrease in half-life, a 50% increase in the volume of distribution, thereby resulting in an almost 3.7-fold increase in total clearance of lorazepam as compared with control healthy females (n=8).
Source: FDA drug label (Lorazepam, NDA018140), Hikma Pharmaceuticals USA Inc., effective April 10, 2024 (SPL set 4084fa74-9fd2-45ef-9d56-27bfa31d4e46), via openFDA
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
What does the norethindrone label say about lorazepam?
Norethindrone's label (effective January 31, 2026) and its 1 other brand-application label do not name lorazepam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lorazepam | Norethindrone | |
|---|---|---|
| Labeled for | Anxiety | Birth control |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0344 per tablet 0.5 mg tablet | $0.290 per tablet 5 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once