What the FDA labels say about taking them together
Lorazepam and loxapine
Lorazepam's FDA label (Lorazepam) of April 10, 2024 names loxapine in its drug interactions section, and loxapine's label names lorazepam too. The lorazepam label: “There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.”
Check it at the source: the lorazepam FDA label on DailyMed (effective July 9, 2025, Bausch Health US LLC); the loxapine FDA label on DailyMed (effective February 26, 2025, Elite Laboratories, Inc.).
What does the lorazepam label say about loxapine?
Lorazepam label (Hikma Pharmaceuticals USA Inc., April 10, 2024), drug interactionsThere have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.
Source: FDA drug label (Lorazepam, NDA018140), Hikma Pharmaceuticals USA Inc., effective April 10, 2024 (SPL set 4084fa74-9fd2-45ef-9d56-27bfa31d4e46), via openFDA
Source: FDA drug label (Ativan), Bausch Health US LLC, effective July 9, 2025 (SPL set 89057c93-8155-4040-acec-64e877bd2b4c), via openFDA; the full label on DailyMed
What does the loxapine label say about lorazepam?
Loxapine label, drug interactionsDrug Interactions There have been rare reports of significant respiratory depression, stupor and/or hypotension with the concomitant use of loxapine and lorazepam.
Source: FDA drug label (Loxapine), Elite Laboratories, Inc., effective February 26, 2025 (SPL set a0cc7bb6-075f-47d1-8935-eb77a29d8c45), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lorazepam | Loxapine | |
|---|---|---|
| Labeled for | Anxiety | Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0344 per tablet 0.5 mg tablet | $0.468 per capsule 10 mg capsule |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once