What the FDA labels say about taking them together
Lopinavir/ritonavir and zidovudine
Lopinavir/ritonavir's FDA label of July 23, 2026 names zidovudine in its drug interactions section; the zidovudine labels PlainMeds reads (3) do not name lopinavir/ritonavir.
Check it at the source: the lopinavir/ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the zidovudine FDA label on DailyMed (effective February 10, 2025, Aurobindo Pharma Limited).
What does the lopinavir/ritonavir label say about zidovudine?
Lopinavir/ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Nucleoside Reverse Transcriptase Inhibitors: abacavir zidovudine; Effect on Concentration of Lopinavir or Concomitant Drug: ↓ abacavir ↓ zidovudine; Clinical Comments: The clinical significance of this potential interaction is unknown.
Source: FDA drug label (Kaletra), AbbVie Inc., effective July 23, 2026 (SPL set 8290add3-4449-4e58-6c97-8fe1eec972e3), via openFDA; the full label on DailyMed
What does the zidovudine label say about lopinavir/ritonavir?
Zidovudine's label (effective February 10, 2025) and its 2 other brand-application labels do not name lopinavir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zidovudine), Aurobindo Pharma Limited, effective February 10, 2025 (SPL set 51abd2ce-6be1-412d-b806-5f24935ac5e3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lopinavir/ritonavir | Zidovudine | |
|---|---|---|
| Labeled for | HIV | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $4.46 per tablet 200-50 mg tablet | $0.464 per tablet 300 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once