What the FDA labels say about taking them together
Lopinavir/ritonavir and tenofovir disoproxil
Lopinavir/ritonavir's FDA label of July 23, 2026 names tenofovir disoproxil in its drug interactions section, and tenofovir disoproxil's label names lopinavir/ritonavir too. The lopinavir/ritonavir label: “Patients receiving KALETRA and tenofovir should be monitored for adverse reactions associated with tenofovir.”
Check it at the source: the lopinavir/ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the tenofovir disoproxil FDA label on DailyMed (effective June 7, 2024, Aurobindo Pharma Limited).
What does the lopinavir/ritonavir label say about tenofovir disoproxil?
Lopinavir/ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Nucleoside Reverse Transcriptase Inhibitor: tenofovir disoproxil fumarate*; Effect on Concentration of Lopinavir or Concomitant Drug: ↑ tenofovir; Clinical Comments: Patients receiving KALETRA and tenofovir should be monitored for adverse reactions associated with tenofovir.
Source: FDA drug label (Kaletra), AbbVie Inc., effective July 23, 2026 (SPL set 8290add3-4449-4e58-6c97-8fe1eec972e3), via openFDA; the full label on DailyMed
What does the tenofovir disoproxil label say about lopinavir/ritonavir?
Tenofovir disoproxil label, drug interactionsNamed in a table that the FDA label file prints without its column breaks; the full label shows the table.
Viread label (Gilead Sciences, Inc., February 18, 2025), drug interactionsNamed in a table that the FDA label file prints without its column breaks; the full label shows the table.
Source: FDA drug label (Viread, NDA021356), Gilead Sciences, Inc., effective February 18, 2025 (SPL set 33fd6418-fbdc-42ca-a50d-ce2a476a5418), via openFDA
Source: FDA drug label (Tenofovir Disoproxil Fumarate), Aurobindo Pharma Limited, effective June 7, 2024 (SPL set a75c6be8-3719-4bb3-8a9e-06e5254d2a82), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lopinavir/ritonavir | Tenofovir disoproxil | |
|---|---|---|
| Labeled for | HIV | HIV, Hepatitis B |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $4.46 per tablet 200-50 mg tablet | $0.294 per tablet 300 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once