What the FDA labels say about taking them together
Loperamide and zanidatamab
Zanidatamab's FDA label of August 24, 2026 names loperamide in its warnings and precautions section; the loperamide label PlainMeds reads does not name zanidatamab.
Check it at the source: the loperamide FDA label on DailyMed (effective June 3, 2026, Aurobindo Pharma Limited); the zanidatamab FDA label on DailyMed (effective August 24, 2026).
What does the loperamide label say about zanidatamab?
Loperamide's label (effective June 3, 2026) does not name zanidatamab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Loperamide Hydrochloride), Aurobindo Pharma Limited, effective June 3, 2026 (SPL set 8e4004be-bf79-4631-9e38-c4e7b6726313), via openFDA; the full label on DailyMed
What does the zanidatamab label say about loperamide?
Zanidatamab label, warnings and precautionsWhen ZIIHERA is used in combination with fluoropyrimidine- and platinum-containing chemotherapy with or without tislelizumab-jsgr, severe, life threatening, and fatal cases of diarrhea can occur despite loperamide prophylaxis [see Adverse Reactions ( 6.1 ), Use in Specific Populations ( 8.5 )].
Source: FDA drug label (ZIIHERA), Jazz Pharmaceuticals, Inc., effective August 24, 2026 (SPL set ae5d9425-fae5-4541-a158-150998343348), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Loperamide | Zanidatamab | |
|---|---|---|
| Labeled for | Diarrhea | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0549 per capsule 2 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once