What the FDA labels say about taking them together
Lonafarnib and loperamide
Lonafarnib's FDA label of July 2, 2025 names loperamide in its drug interactions section; the loperamide label PlainMeds reads does not name lonafarnib. The lonafarnib label: “Clinical Impact; Lonafarnib is a weak inhibitor of P-gp and strong inhibitor of CYP3A. Coadministration of ZOKINVY with loperamide increases the AUC and C max of loperamide which may increase the risk of loperamide's …”
Check it at the source: the lonafarnib FDA label on DailyMed (effective July 2, 2025, Sentynl Therapeutics, Inc.); the loperamide FDA label on DailyMed (effective June 3, 2026, Aurobindo Pharma Limited).
What does the lonafarnib label say about loperamide?
Lonafarnib label, drug interactionsClinical Impact; Lonafarnib is a weak inhibitor of P-gp and strong inhibitor of CYP3A. Coadministration of ZOKINVY with loperamide increases the AUC and C max of loperamide [see Clinical Pharmacology ()] which may increase the risk of loperamide's adverse reactions.
Source: FDA drug label (Zokinvy), Sentynl Therapeutics, Inc., effective July 2, 2025 (SPL set 97391d0c-943e-4c5a-8423-68e163aa7f50), via openFDA; the full label on DailyMed
What does the loperamide label say about lonafarnib?
Loperamide's label (effective June 3, 2026) does not name lonafarnib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Loperamide Hydrochloride), Aurobindo Pharma Limited, effective June 3, 2026 (SPL set 8e4004be-bf79-4631-9e38-c4e7b6726313), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lonafarnib | Loperamide | |
|---|---|---|
| Labeled for | n/a | Diarrhea |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0549 per capsule 2 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once