What the FDA labels say about taking them together
Lofexidine and paroxetine
Lofexidine's FDA label of July 22, 2026 names paroxetine in its drug interactions section; the paroxetine labels PlainMeds reads (4) do not name lofexidine. The lofexidine label: “Concomitant use of paroxetine resulted in increased plasma levels of LUCEMYRA.”
Check it at the source: the lofexidine FDA label on DailyMed (effective July 22, 2026, BioCorRx Pharmaceuticals Inc); the paroxetine FDA label on DailyMed (effective February 12, 2026, Mylan Pharmaceuticals Inc.).
What does the lofexidine label say about paroxetine?
Lofexidine label, drug interactionsConcomitant use of paroxetine resulted in increased plasma levels of LUCEMYRA.
Source: FDA drug label (LUCEMYRA), BioCorRx Pharmaceuticals Inc, effective July 22, 2026 (SPL set 0a848cc2-4dda-40d9-8b01-d789fe8981ed), via openFDA; the full label on DailyMed
What does the paroxetine label say about lofexidine?
Paroxetine's label (effective February 12, 2026) and its 3 other brand-application labels do not name lofexidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Paroxetine), Mylan Pharmaceuticals Inc., effective February 12, 2026 (SPL set 89dd7e24-85fc-4152-89ea-47ec2b48a1ed), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lofexidine | Paroxetine | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety, Menopause symptoms |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $7.88 per tablet 0.18 mg tablet | $0.0611 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once