What the FDA labels say about taking them together
Lofexidine and naltrexone
Lofexidine's FDA label of July 22, 2026 names naltrexone in its drug interactions section; the naltrexone labels PlainMeds reads (2) do not name lofexidine. The lofexidine label: “ECG monitoring is recommended when used concomitantly. Oral Naltrexone: Concomitant use may reduce efficacy of oral naltrexone.”
Check it at the source: the lofexidine FDA label on DailyMed (effective July 22, 2026, BioCorRx Pharmaceuticals Inc); the naltrexone FDA label on DailyMed (effective September 4, 2026).
What does the lofexidine label say about naltrexone?
Lofexidine label, drug interactionsECG monitoring is recommended when used concomitantly. ( 7.1 ) Oral Naltrexone: Concomitant use may reduce efficacy of oral naltrexone.
Source: FDA drug label (LUCEMYRA), BioCorRx Pharmaceuticals Inc, effective July 22, 2026 (SPL set 0a848cc2-4dda-40d9-8b01-d789fe8981ed), via openFDA; the full label on DailyMed
What does the naltrexone label say about lofexidine?
Naltrexone's label (effective September 4, 2026) and its 1 other brand-application label do not name lofexidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (NALTREXONE HYDROCHLORIDE), SpecGx LLC, effective September 4, 2026 (SPL set 06ff2d5a-e62b-4fa4-bbdb-01938535bc65), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lofexidine | Naltrexone | |
|---|---|---|
| Labeled for | n/a | Alcohol use disorder, Opioid use disorder |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $7.88 per tablet 0.18 mg tablet | $1.14 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once