What the FDA labels say about taking them together
Lofexidine and methadone
Lofexidine's FDA label of July 22, 2026 names methadone in its drug interactions section; the methadone labels PlainMeds reads (4) do not name lofexidine. The lofexidine label: “DRUG INTERACTIONS Methadone: Methadone and LUCEMYRA both prolong the QT interval.”
Check it at the source: the lofexidine FDA label on DailyMed (effective July 22, 2026, BioCorRx Pharmaceuticals Inc); the methadone FDA label on DailyMed (effective December 8, 2025, Epic Pharma, LLC).
What does the lofexidine label say about methadone?
Lofexidine label, drug interactionsDRUG INTERACTIONS Methadone: Methadone and LUCEMYRA both prolong the QT interval.
Lofexidine label, warnings and precautionsMonitor ECG in patients with congestive heart failure, bradyarrhythmias, hepatic impairment, renal impairment, or patients taking other medicinal products that lead to QT prolongation (e.g., methadone).
Source: FDA drug label (LUCEMYRA), BioCorRx Pharmaceuticals Inc, effective July 22, 2026 (SPL set 0a848cc2-4dda-40d9-8b01-d789fe8981ed), via openFDA; the full label on DailyMed
What does the methadone label say about lofexidine?
Methadone's label (effective December 8, 2025) and its 3 other brand-application labels do not name lofexidine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methadone Hydrochloride), Epic Pharma, LLC, effective December 8, 2025 (SPL set 6da7501b-b881-4bc7-891a-74214a00a3ac), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lofexidine | Methadone | |
|---|---|---|
| Labeled for | n/a | Pain, Opioid use disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $7.88 per tablet 0.18 mg tablet | $0.177 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once