What the FDA labels say about taking them together
Lithium and sodium chloride
Sodium chloride's FDA label of June 30, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name sodium chloride. The sodium chloride label: “Lithium Renal sodium and lithium clearance may be decreased during administration of Sodium Chloride Injection, USP.”
Check it at the source: the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA); the sodium chloride FDA label on DailyMed (effective June 30, 2025, Baxter Healthcare Corporation).
What does the lithium label say about sodium chloride?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name sodium chloride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
What does the sodium chloride label say about lithium?
Sodium chloride label, drug interactionsLithium Renal sodium and lithium clearance may be decreased during administration of Sodium Chloride Injection, USP.
Source: FDA drug label (Sodium Chloride, NDA018016), Baxter Healthcare Corporation, effective July 24, 2024 (SPL set f55bd888-5e01-474d-871b-24654c070178), via openFDA
Source: FDA drug label (Sodium Chloride, NDA019022), Baxter Healthcare Corporation, effective May 23, 2018 (SPL set 181705c7-40e4-4d7d-b9ea-ada99380e7a9), via openFDA
Source: FDA drug label (SODIUM CHLORIDE), Baxter Healthcare Corporation, effective June 30, 2025 (SPL set 958d35f0-6834-43be-a700-fa58f38b4c19), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lithium | Sodium chloride | |
|---|---|---|
| Labeled for | Bipolar disorder | Cough and cold |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.104 per capsule 300 mg capsule | $0.0887 per mL 0.9% vial |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once