What the FDA labels say about taking them together
Lithium and rocuronium
Rocuronium's FDA label of July 16, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name rocuronium. The rocuronium label: “Inhalation anesthetics, certain antibiotics, quinidine, magnesium, lithium, local anesthetics, procainamide Reduced Rocuronium Bromide Injection activity possible:”
Check it at the source: the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA); the rocuronium FDA label on DailyMed (effective July 16, 2025, Fresenius Kabi USA, LLC).
What does the lithium label say about rocuronium?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name rocuronium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
What does the rocuronium label say about lithium?
Rocuronium label, drug interactionsInhalation anesthetics ( 7.3 ), certain antibiotics ( 7.1 ), quinidine ( 7.10 ), magnesium ( 7.6 ), lithium ( 7.4 ), local anesthetics ( 7.5 ), procainamide ( 7.8 ) Reduced Rocuronium Bromide Injection activity possible:
Rocuronium label, warnings and precautionsCertain inhalation anesthetics, particularly enflurane and isoflurane, antibiotics, magnesium salts, lithium, local anesthetics, procainamide, and quinidine have been shown to increase the duration of neuromuscular block and decrease infusion requirements of neuromuscular blocking agents [see Drug Interactions ( 7.3 )].
Source: FDA drug label (Rocuronium Bromide, NDA219108), B. Braun Medical Inc., effective July 17, 2026 (SPL set a54a79f7-5207-43d8-a139-7d57557caa50), via openFDA
Source: FDA drug label (Rocuronium), Fresenius Kabi USA, LLC, effective July 16, 2025 (SPL set 9a622308-7bda-4ca0-9de5-d6b3b4be3384), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lithium | Rocuronium | |
|---|---|---|
| Labeled for | Bipolar disorder | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.104 per capsule 300 mg capsule | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once