What the FDA labels say about taking them together
Lithium and mannitol
Mannitol's FDA label of August 26, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name mannitol. The mannitol label: “However, concomitant use of mannitol and lithium may increase risk of lithium toxicity.”
Check it at the source: the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA); the mannitol FDA label on DailyMed (effective August 26, 2025, Baxter Healthcare Company).
What does the lithium label say about mannitol?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name mannitol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
What does the mannitol label say about lithium?
Mannitol label, drug interactionsHowever, concomitant use of mannitol and lithium may increase risk of lithium toxicity.
Source: FDA drug label (Osmitrol), Baxter Healthcare Company, effective August 26, 2025 (SPL set 0d914965-7001-45cb-ba51-d7c5964b05bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lithium | Mannitol | |
|---|---|---|
| Labeled for | Bipolar disorder | Edema (fluid retention) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.104 per capsule 300 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once